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Breakthrough: Elizabeth Hughes, the Discovery of Insulin, and the Making of a Medical Miracle, by Thea Cooper, Arthur Ainsberg
PDF Download Breakthrough: Elizabeth Hughes, the Discovery of Insulin, and the Making of a Medical Miracle, by Thea Cooper, Arthur Ainsberg
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It is 1919 and Elizabeth Hughes, the eleven-year-old daughter of America's most-distinguished jurist and politician, Charles Evans Hughes, has been diagnosed with juvenile diabetes. It is essentially a death sentence. The only accepted form of treatment – starvation – whittles her down to forty-five pounds skin and bones. Miles away, Canadian researchers Frederick Banting and Charles Best manage to identify and purify insulin from animal pancreases – a miracle soon marred by scientific jealousy, intense business competition and fistfights. In a race against time and a ravaging disease, Elizabeth becomes one of the first diabetics to receive insulin injections – all while its discoverers and a little known pharmaceutical company struggle to make it available to the rest of the world.
Relive the heartwarming true story of the discovery of insulin as it's never been told before. Written with authentic detail and suspense, and featuring walk-ons by William Howard Taft, Woodrow Wilson, and Eli Lilly himself, among many others.
- Sales Rank: #223379 in Books
- Published on: 2010-09-14
- Released on: 2010-09-14
- Original language: English
- Number of items: 1
- Dimensions: 9.58" h x 1.18" w x 6.38" l, 1.13 pounds
- Binding: Hardcover
- 320 pages
From Booklist
Cooper and Ainsberg present an inspirational record of how the confluence of just the right people at just the right time in just the right places launched a boon for diabetics the world over. When Elizabeth Hughes Gossett was laid to rest in 1981 at the age of 73, few people knew that, by all rights, she should never have lived long enough to enter high school, much less graduate college, marry, and have children. Fewer still may have known or appreciated that while still a child, she risked what little life she may have had left by participating in a medical experiment that, if successful, would save her own and millions of other lives. A remarkable story, made more so by the efforts of Frederick Banting, who tipped fate in Elizabeth’s favor. Just as the honeybee believes its wings will carry it through the air against all physical odds, Banting believed he could perfect a product—insulin—that would save the lives of diabetics. Bees fly and Banting did, and this account makes worthy reading. --Donna Chavez
Review
“The twentieth century witnessed many medical miracles, but perhaps none was so transformative as the discovery of insulin for the treatment for diabetes. Breakthrough is the fascinating tale of Nobel prize-winning research, of a young girl who should have died as a child but instead lived to see seven grandchildren, and of a drug that turned a death sentence into something more akin to a chronic nuisance. This book is an important read for anyone with diabetes. It is an enjoyable read for those who love mystery and human drama.” ―Kenneth T. Jackson, Barzun Professor of History, Columbia University
About the Author
THEA COOPER is an author, playwright, editor and teacher. ARTHUR AINSBERG is an author and financial industry veteran whose successful battle with Hodgkin's disease sparked his interest in medical history.
Most helpful customer reviews
13 of 17 people found the following review helpful.
Interesting
By Amazon Customer
This book details the discovery of insulin and how that discovery affected the lives of Elizabeth Hughes and her family. Cooper, a playwright, and Ainsberg, an author, put together this book as a collaborative project. The book juxtaposes the details of the discovery and development of insulin as a therapy for diabetes with the diagnosis and subsequent health decline of Elizabeth Hughes, daughter of Charles Evans Hughes. Elizabeth Hughes was first diagnosed with diabetes in April 1919 at the age of 12. At that time, the best therapy for diabetes was Allen's starvation treatment, in which patients were put on a strict dietary regime which kept them on a knife's edge between sugar poisoning and outright starvation; indeed, as Cooper and Ainsberg note in this book, many of Allen's patients succumbed to starvation. Allen's severe dietary restrictions were no cure for diabetes, but merely a stopgap measure, with the hope that it would enable patients to survive long enough for a diabetes cure to be found. Elizabeth Hughes was one of the Allen's most famous patients, and one of the first for whom the starvation gamble paid off when insulin treatments began to be tested on human patients in 1922.
This book delves into the gritty details of the discovery and development of insulin, how a young doctor named Frederick Banting with no research experience but a unique idea was able to persuade veteran Toronto researcher Charles Best to let him try a summer project in his lab. Cooper and Ainsberg relate the details of Banting and Best's subsequent strife-filled collaboration. They also discuss the family background of Elizabeth Hughes and her well-known father, Charles Evans Hughes. They consider the ethical questions of Elizabeth's treatments with Allen and Banting, and conjecture some of the ethical questions that Charles Evans Hughes may have been faced with when making decisions concerning his daughter's treatments.
The book provides informative details about the bleak situation for diabetes patients before 1920, and a glimpse into the difficulties faced by many collaborative research efforts. I found the focus on Elizabeth Hughes a bit misleading though; rather than being the first patient successfully treated with insulin injections, she was more a famous exemplar rather than a pioneer. The book is rife with descriptions of conversations and mental states; in looking for references to describe how the authors may have been able to uncover such intimate material, I found instead that they had made it up. Indeed, one of the book's most important scenes depicts an ethical quandary faced by Charles Evans Hughes, yet in the sources, the authors write "The phone call from Charles Evans Hughes to President Falconer at the University of Toronto is imagined, as is Antoinette's urging him to it." If such details were invented for dramatic emphasis, then this book must be approached as a work of fiction, not of medical history.
3 of 3 people found the following review helpful.
A very informative and entertaining book
By The Reviewer Formerly Known as Kurt Johnson
When I was a mere eleven years old, my parents noticed my brother attempting to smuggle a pitcher of water up to his bedroom. He admitted that he had been drinking a lot of late, and my parents became alarmed. Rushing him off to the hospital he was quickly diagnosed with type 1 diabetes. It was a strange and frightening time for the whole family, and I read everything I could on the disease to get an understanding of what was happening to my brother.
This book, takes the reader back in time to that amazing transitional time in 1922 when the diagnosis of diabetes changed from being a sentence of death, when the discovery of insulin gave so many people world-wide back their lives. It looks at the victims of the disease, focusing primarily on Elizabeth Hughes, daughter of the Secretary of State of the United States, and looks at the researchers whose activities resulted in the most important breakthrough in the treatment of the disease.
First off, I must agree that this book does take the barebones story of what happened in 1922 and before, fleshes it out with a good deal of "imagined" detail. Therefore this book is probably not terribly useful to someone who wants a reliable and scholarly history.
What this book is is more of what I would call a "popular history," that is, a book written to tell the story of the discovery of insulin, but in an entertaining and engaging manner. I for one found this to be a very informative and entertaining book. The early part that dealt with what families went through before the discovery of insulin was quite literally heartbreaking. And I must admit that when I got to the part where peoples lives were being returned to them (as opposed to living in a concentration camp-like sanitarium), I quite literally got tears in my eyes.
Yes, I really enjoyed this book, and am very glad that I read it. As someone at least somewhat knowledgeable about diabetes, I was interested to learn about what diabetes was like before there was insulin, and how much better things are today. I don't hesitate to recommend this book.
5 of 6 people found the following review helpful.
Good story, bad title.
By Brian J. Rodriguez
Just finished the book and as a type 1 diabetic (23 years now) I have to say it was pretty interesting. I like reading about the trials and tribulations of the work Banting and Best did. The story of Elizabeth Hughes, while interesting, really got in the way of the actual Breakthrough portion of the story.
Reading her parts left me with a feeling of "so what?" I would have rather had more time and pages devoted to Banting and Best. I understand telling her story was for dramatic effect but in the end I feel her story just fell flat. I think, in part, that has to do with the fact that she hid her diabetes for the rest of her life. I understand that is a product of the times she was brought up in but really this breakthrough story was about the discovery of insulin, not a little girl who happened to use parental influence to get said insulin and hide her disease for the rest of her life.
The other thing that bothered me about the book was the authors' making up conversations and situations that they explicitly state either did not or could not have happened. I understand the want for drama but when talking about such an important subject I found it to be a little over the top and call into question how factual they were being on other portions of the book.
In the end the book is a good read about a subject and drug near and dear to me. So would I recommend it? Yes, with the caveat that the reader do further research to get the real story about insulin and its discovery.
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